ChE 4800/5800 Biochemical Engineering (Spring 2017)

Time: MWF 12:55 PM to 1:50 PM

Classroom: ARC 212
Instructor: Tingyue Gu (

TA: Roy Jia (
Office: Stocker 167B, Office Phone: 593-1499
Office Hours: Drop in when I am in my office

Optional textbook
Bioprocess Engineering by Michael L. Shuler and Fikret Kargi, Prentice Hall, Englewood Cliffs, 2nd Edition, 2002. (If you have the 1st edition, use it. You may also share a textbook among your classmates. It is easy to borrow the textbook from OhioLink.)

Reference books
1. Biochemistry by J. M. Berg et al., 6th Edition, W. H. Freeman & Co., San Francisco, 2006.
2. James E. Bailey and David F. Ollis, Biochemical Engineering Fundamentals, McGraw Hill, New York, 1986.
3.  Harvey W. Blanch and Douglas S. Clark, Biochemical Engineering, Marcel Dekker, New York, 1996.
4.  Raul J. Cano and Jaime S. Colome, Microbiology, West Publishing Co., St. Paul, 1986 (or other similar and newer books).

Homework Assignments and Handouts are here.  If any file has a password, it will be 1234. Blackboard is used only for grades. E-mail submission must receive a reply as receipt from instructor. Otherwise, lost submission will be your problem.

Final grade
The weights are 20% homework, 10% lab project, 10% term paper, 30% midterm and 30% final exam. An overall of 91% will guarantee an A, and 80% B, and 70% C, and 60% D. Excuses for missing an exam must be accepted before it happens. Missing too many lectures will lead to a lower grade. Exams are closed-book. Grades are posted on Blackboard. It is your responsibility to inform the instructor of any error in grading before it is too late. 


Brief syllabus
Weeks 1 - 2:  Basics of biology 
Weeks 2 - 3:  Enzyme kinetics 

Week 4: Biomass utilization and bioenergy
Week 5:  Genetics and cell metabolism 
Week 6: Major metabolic pathways 

Weeks 7 - 8: Cell growth kinetics  (Midterm right before Spring Break)

Week 8: Stoichiometry of cell growth and product formation (1 class). 
Week 9: Recombinant DNA technology. Start lab experiment.
Weeks 10 - 11:  Batch culture and chemostat 
Week 12: Reactor control and scale-up
Week 13: Sterilization 
Weeks 13-15: Bioseparations 

Guidelines for homework and term paper   
Homework must be handed in at the beginning of the class. In your homework solutions, you must use PC for plots. You must attach your original plots. Penalties will be given for missing units. Homework must be stapled before submission. Details are required. Late submissions incur a penalty of 20% per day with a 10% minimum. The term paper must be typed and spell-checked. The length is 10-15 double-spaced pages for graduate students and 7-10 for undergraduates. A typical term paper is much like a literature review paper with a focused subject. A good term paper should have page numbers and section titles. It should be an in-depth technical review based mostly on journal papers rather than web sites. If you think your paper could have been written by a journalist or a high school student (rather than an engineer), it likely lacks the needed technical depth. A term paper citing a few web sites is inadequate. Second-hand citing must be avoided. Read and cite the original paper. Your paper will be graded based on organization, understanding and interpretation of the state of the art, technical depth, language, and literature coverage. Detailed format guidelines will be discussed in class. The paper is due at the beginning of the first class in the week just before the finals week. You must submit the term paper via Blackboard. It will be scanned by TurnItIn software for plagiarism. The lab project report is due at the beginning of the final exam. Hard copy or soft copy can be submitted. 


Attendance policy

Attendance is mandatory. Classroom discussion details may be tested in exams. Missing a class requires a good excuse.

Policy on plagiarism
You may discuss homework problems with your classmates. However, plagiarism is strictly prohibited according to relevant OU regulations. Cheatings on assignments, quizzes and exams may result in a grade of F in the course. University Judiciaries may impose additional sanctions. For more information please check out the section entitled "Academic Misconduct" in the Ohio University Student Handbook.  Students may appeal academic sanctions through the grade appeal process.